ABSTRACT
During the preparation of anti-cancer drugs, mutual verification with another pharmacist is performed to prevent preparation mistakes. In a small-to-medium sized hospital with relatively few pharmacists, it is common for nurses to perform verifications. The nurses approach the safety cabinet only lightly protected by their clothing. Thus, occupational exposure to anti-cancer drugs, which are hazard drugs is a concern. To prevent occupational exposure, we implemented and investigated the effectiveness of an “anti-cancer drug preparation camera support system”, which allowed two-way communication and video recording between an anti-cancer drug preparation room and a pharmacy preparation room at different locations. The amount of exposure to anti-cancer drugs was defined as the time required to verify the anti-cancer drug. The average daily exposure time was calculated based on the number of verifications and the average time for each verification. This value was then compared with the exposure time when the camera system was implemented. In addition, the frequency of work interruption when a pharmacist verified, after the introduction, was assessed. The effectiveness of the camera supported system was validated, the verification time for anti-cancer drugs was reduced from 48.9±9.3 minutes/day to 4.4±0.9 minutes/day. This means that the occupational exposure time of 48.9±9.3 min/day for nurses was reduced to zero and the occupational exposure time for dispensing pharmacists was reduced to 4.4±0.9 min/day. In addition, it allowed pharmacists to properly confirm anti-cancer drugs preparations.
ABSTRACT
Objective:To establish a calculation model of drug preparation difficulty coefficient for outpatient pharmacy intrave -nous admixture center ( OUIVA) in a children's hospital, and construct the performance model .Methods: All the prescriptions in a week in OUIVA of Shanghai children's medical center were randomly selected .According to the actual difficulty level in the process of outpatient and emergency drug preparation , a basic drug difficulty coefficient and difficulty coefficient addition method was constructed . The difficulty index of every prescription was calculated .All the prescriptions in a week were randomly selected , and according to the difficulty coefficient analysis method , the daily difficulty coefficient of the prescriptions was calculated in order to build a performance model for OUIVA in the hospital .Results:The difficulty coefficient of medicine mainly included four basic difficulty coefficients and nine difficulty addition coefficients .According to the statistics , the average difficulty coefficient of daily prescriptions was (3.83 ± 2.86 )with the highest difficulty coefficient of 35, and the prescription data showed that there was significant difference between outpa -tient and emergency prescriptions and daytime blood tumor prescriptions .Conclusion:A performance model based on the difficulty co-efficient for OUIVA in children ' s hospital is a more scientific reflection to the daily work .
ABSTRACT
Objective: To prepare ginsenoside Rg3-loaded chitosan microspheres for intranasal administration. Methods: The chitosan microspheres were prepared by the O/W/O combined with multiple emulsification chemical crosslink technique. Quadratic polynomial equation and linear regression equation were fitted by the statistic software, and the resulting equations were used to produce response surface graphs. The best experiment conditions were screened by central composite design (CCD) using drug load, encapsulation efficiency, and the proportions of microspheres (with diameter of 40-60 μm) as variables. The shape of microspheres was observed by scanning electron microscope. Results: The best ranges of the prescription included: drug to carrier material ratio-0. 4-0. 5;organic phase and water phase ratio:0. 4-0. 6;and first emulsion and oil phase ratio:0. 13-0. 17. The 3 batches of microspheres prepared according to the above condition were well-shaped (full sphere), with the mean drug loading capacity being (10. 25 ± 0. 08) % and the encapsulation efficiency being (30. 61 ± 1. 46) %. Conclusion: The optimized technique has a good reproducibility and can be used for preparation of Rg3-loaded chitosan microspheres for intranasal administration.
ABSTRACT
OBJECTIVE:To provide references for drug pricing and drug administration for Chinese government.METHODS:The drug pricing and administration policies in UK were expounded and the effects of which were analyzed and evaluated,based on which some suggestions were put forward with the consideration of the specific condition of our country.RESULTS&CONCLUSIONS:The rules of market economy should be obeyed and market monitoring should be carried out in China.The non-governmental organizations should play a key role in the support and service for national drug supervision and administration.The drug prices should be controlled according to category so as to make the formula process of drug price policy scientific.The government-set price and the market price monitoring mechanism should be established and the legal system of drug price management should be established as soon as possible.
ABSTRACT
Objective:To prepare ginsenoside Rg3-loaded chitosan microspheres for intranasal administration.Methods:The chitosan microspheres were prepared by the O/W/O combined with multiple emulsification chemical crosslink technique.Quadratic polynomial equation and linear regression equation were fitted by the statistic software,and the resulting equations were used to produce response surface graphs.The best experiment conditions were screened by central composite design(CCD)using drug load,encapsulation efficiency,and the proportions of microspheres(with diameter of 40-60 ?m)as variables.The shape of microspheres was observed by scanning electron microscope.Results:The best ranges of the prescription included:drug to carrier material ratio:0.4-0.5;organic phase and water phase ratio:0.4-0.6;and first emulsion and oil phase ratio:0.13-0.17.The 3 batches of microspheres prepared according to the above condition were well-shaped(full sphere),with the mean drug loading capacity being(10.25?0.08)% and the encapsulation efficiency being(30.61?1.46)%.Conclusion:The optimized technique has a good reproducibility and can be used for preparation of Rg3-loaded chitosan microspheres for intranasal administration.